·7CHINESEJOURNALOFCTANDMRI,FEB.2023,Vol.21,No.02TotalNo.160【第一作者】祝华强，男，副主任医师，主要研究方向：头颈部、骨肌系统影像诊断。E-mail：dgzhuhuaqiang@163.com【通讯作者】祝华强论著MultimodalMRICharacteristicAnalysisofAdultH3K27MMutantDiffuseMidlineGliomaZHUHua-qiang1,*,WANGDong-ye2,MAOJia-ji2,XULin-sen1,SHENjun2.1.DepartmentofMedicalImaging,UniversityofChineseAcademyofSciencesShenzhenHospital(Guangming),Shenzhen518106,GuangdongProvince,China2.DepartmentofRadiology,SunYat-senMemorialHospital,SunYat-senUniversity,Guangzhou510120,GuangdongProvince,ChinaABSTRACTObjectiveToinvestigatethemultimodalMRImanifestationsofadultH3K27Mmutantdiffusemidlineglioma,improvethediagnosisaccuracyofthedisease,andprovideimagingreferenceforthistypeoftumor.MethodsTheclinicalandimagingdataof12casesofadultH3K27MmutantdiffusemidlinegliomaconfirmedbyclinicopathologyfromJanuary2017toMay2021wereretrospectivelyanalyzed.Results12casesofH3K27Mmutantdiffusemidlineglioma(10malesand2females),including4casesofthalamus(3casesontherightsideand1caseontheleftside);5casesofbrainstem(2casesofponsand3casesofmedullaoblongata));2casesofcervicalthoracicspinalcord;1caseofcerebellarvermis.All12casesweresinglelesions,11casesweresolid,1casewascystic,andspinalcordtumorswerealllong-segmentlesions.ThesignalonMRIwasrelativelyuniform;4caseswithmildedema;6caseswithlesionswithnecrosis,1casewithhemorrhage,6caseswithhydrocephalus;7caseswithDWIlesionsshowedvaryingdegreesofdiffusionrestriction,7caseswithflowEmptybloodvesselsignal;12casesshowedenhancement,ofwhich10casesshowedunevenenhancement;9casesofMRSshowedthattheChopeakincreasedtodifferentdegrees,theNAApeakdecreasedtodifferentdegrees,and1caseshowedatallLippeak;4casesperformeddiffusiontensorimaging(DTI)showedsparsenervefiberbundlesinthelesionarea,2caseswerepartiallydamagedandinterrupted,and2casesnervefiberbundleswerecompressedanddisplaced.ConclusionAdultH3K27MmutantdiffusemidlinegliomamultimodalMRImanifestationsarediverse,butstillhaverelativelycharacteristicmanifesta...
