566Cell136,February6,2009©2009ElsevierInc.DOI10.1016/j.cell.2009.01.011Seeonlineversionforlegendandreferences.SnapShot:MicrotubuleRegulatorsIIKarenLyle,PraveenKumar,andTorstenWittmannDepartmentofCellandTissueBiology,UniversityofCalifornia,SanFrancisco,CA94143,USAProteinfamilyBiochemicalfunctionRepresentativeProteinsH.sapiensD.melanogasterC.elegansA.thalianaS.cerevisiaeS.pombeclassicalmicrotubule-AssociatedProteinsMAP1stabilizesneuronalmicrotubulesMAP1A,MAP1B,MAP1SfutschMAP2/Tauinhibitdepolymerization,increasemicrotubulerigidity*Tau,MAP2,MAP4TauPTL-1Mhp1microtubule-BundlingProteinsKinesin-5(BimC)crosslinksandslidesantiparallelmicrotubulesEg5Klp61FBMK-1AtKRP125cKip1,Cin8Cut7MAP65promotesantiparallelmicrotubulebundlingPRC1Feo(fascetto)SPD-1AtMAP65-1,2,3,4,5,6,7,8,PLEAse1Ase1WVD2bundlesmicrotubulesWVD2,WDLmicrotubulestabilizationthroughcellcortexInteractionsAPCmediatesinteractionswithcorticalcytoskeleton,promotesnetgrowth*APC,APC2dAPC1,dAPC2APR-1(Kar9)Bud6corticalcaptureofastralmicrotubulesBud6CLASPsmediateinteractionswithcellcortex,kinetochores,andGolgiCLASP1,CLASP2Orbit/MASTCLS-2CLASPStu1Peg1SpectraplakinslinkmicrotubulestotheactincytoskeletonMACF1/ACF7,*MACF2/BPAG1shot(shortstop)VAB-10microtubule-stabilizingProteinswithmitosis-specificfunctionsKinesin-7capturesmicrotubulesatkinetochoresCENP-EcmetKip2Tea2AstrincrosslinksmicrotubulesSpag5HURPwrapstubulinsleevesaroundmicrotubules*DLGAP5NuMAstabilizesspindlepolemicrotubulesNUMAMud(mushroombodydefect)NuSAPstabilizesmicrotubulesnearchromosomesNuSAPRHAMMstabilizesmicrotubulesatspindlepolesRHAMMTACCproteinsstabilizemicrotubulesatspindlepoles*TACC-1,TACC-2,TACC-3D-TACCTAC-1Alp7TPX2stabilizesspindlepolemicrotubulesTPX2TPXL-1AtTPX2othermicrotubule-stabilizingProteinsCLAMPstabilizesmicrotubulesCLAMPDoublecortinstabilizesmicrotubulesduringneuronalmigration*DCXZYG-8ForminsstabilizemicrotubulesbydecreasingdisassemblyDia1,Dia2,INF1Dia(diaphanous)Bni1Lis1stabilizesmicrotubulesduringneuronalmigration*LIS1Lis-1LIS-1MAP6/STOPprotect...
