CellSignalingTechnology©2003–2018CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationTranscriptionalInhibitoryModificationPathwayDiagramKeyAngiogenesisVHLCul2Rbx1TCEB2TCEB1PHDselF4E14E-BP1Erk1/2Erk1/2MNKMEK1/2RasS6KmTORAktPI3KCBP/p300HIF1αHIF1αHIF1βHIF1βHIF1αPI3KSrcNOSAktFAKPLCλErk1/2Smad2/3p38MAPKHIF1αHIF1αMatrixRemodelingPAI-1MMPCox2OHOHOHNormoxiaNucleusVEGFR2VEGFTie2FGFRIGFREGFRPDGFR-βPDGF-BBROBOSLITNotchE3LigaseComplexDegradation•GrowthFactors•Cytokines•ECMProteasesExtracellularMatrixEndothelialCellPericyteNormoxiaNormoxiaHypoxiaAngiogenesisBloodVesselVascularGuidanceCellFateVascularPermeabilitySurvivalMigrationProliferationPericyteProliferationTargetGenesHREBasementMembraneCytoplasmPro-AngiogenicCellExtracellularSpacerev.08/24/18rev.08/24/18
