131研究探讨《食品工业》2023年第44卷第2期氨糖软骨素钙姜黄复合物对骨密度的协同作用何晶，邱春媚，黄远英，殷光玲，张旭光汤臣倍健股份有限公司（广州510663）摘要研究采用动物试验,评估一种氨糖软骨素钙姜黄复合物对骨密度的影响及其安全性。复合物给予剂量为0.345,0.690和2.070g/(kg·bw)。通过试验考察动物生长发育情况,2.070g/(kg·bw)剂量组大鼠股骨中心和远心端骨密度,骨钙含量显著高于溶剂对照组(P＜0.05),氨糖软骨素钙姜黄复合物对于大鼠有增加骨密度的作用。通过小鼠的急性毒性试验、Ames试验及小鼠精子畸形试验,评估氨糖软骨素钙姜黄复合物的安全性。试验结果表明,氨糖软骨素钙姜黄复合物对小鼠未见明显毒性,试验动物均未产生异常反应,试验为阴性结果。氨糖软骨素钙姜黄的组合对骨密度有积极影响,且具有较好的安全性。试验结果为氨糖、软骨素、钙及姜黄的组合使用及相关食品开发提供研究基础。关键词骨密度;氨糖;软骨素;钙;姜黄SynergisticEffectoftheCompoundofGlucosamineChondroitinCalciumandCurcuminonBoneMineralDensityHEJing,QIUChunmei,HUANGYuanying,YINGuangling,ZHANGXuguangBy-HealthCo.,Ltd.(Guangzhou510663)AbstractAnimalexperimentswereusedtoevaluatetheeffectofaglucosaminechondroitincalciumandcurcumincompositiononbonemineraldensityanditssafety.Dosageofglucosaminechondroitincalciumandcurcumincompositionwas0.345,0.690and2.070g/(kg·bw).Thegrowthofanimalswasinvestigatedthroughexperiments,bonemineraldensityinthecenteranddistalendoffemurandbonecalciumcontentin2.070g/(kg·bw)dosegroupweresignificantlyhigherthanthoseinsolventcontrolgroup(P＜0.05).Throughtheacutetoxicitytest,Amestestandspermmalformationtestinmice,thesafetyoftheglucosaminechondroitincalciumandcurcumincompositionwasevaluated.Theexperimentalresultsshowedthatthecompoundofglucosaminechondroitincalciumandcurcuminhadnoobvioustoxicitytomice,theexperimentalanimalshadnoabnormalreaction,andtheexperimentwasnegative.Accordingtotheresearch,thecompoundofglucosaminechondroitincalciumandcurcuminhadapositiveeffectonbonemineraldensity,andhadgoodsafety.Itprovidedaresearchbasisforthecompoundofglucosaminechondroitincalciumandcurcuminandthedevelopmentofrelatedfoods.Keywordsbonemineral...
