文章编号:1673-2995(2023)04-0252-03·论著·萱草花黄酮对阿尔茨海默病大鼠脑、肝组织的影响李治伟，罗小琴*，徐向，周峰，石佳鹭(长沙卫生职业学院，湖南长沙410006)摘要:目的评价萱草花黄酮(Hemerocallisflavone，HCF)对阿尔茨海默病(Alzheimer＇sdisease，AD)大鼠脑组织和肝组织氧化应激的影响，探讨应用其降低AD氧化应激水平的可能性。方法SD大鼠24只，随机分3组，即空白对照组、AD模型对照组、HCF组。氯化铝灌胃结合D半乳糖腹腔注射制备AD模型;分别检测各组大鼠脑组织和肝组织匀浆中丙二醛(malondialdehyde，MDA)含量、超氧化物歧化酶(superoxidedismutase，SOD)和过氧化氢酶(catalase，CAT)活力;单因素方差分析进行数据分析，组间比较采用LSD-t检验。结果与空白对照组比较，AD模型大鼠脑组织MDA含量增加，SOD、CAT活力降低;与AD模型组比较，HCF组脑组织MDA含量降低，肝组织SOD、CAT活力升高，肝组织CAT活力升高，SOD活力无明显变化。结论HCF可通过升高抗氧化酶SOD和CAT活力增强机体和脑组织的抗氧化能力，降低AD脑组织和机体的氧化应激水平。关键词:萱草花;黄酮;阿尔茨海默病;大鼠;氧化应激中图分类号:Ｒ961文献标志码:AEffectsofflavonoidsfromHemerocallisfulvaonbrainandlivertissuesofAlzhei-mer＇sdiseaseratsLIZhiwei，LUOXiaoqin*，XUXiang，ZHOUFeng，SHIJialu(ChangshaHealthVocationalCollege，Changsha，HunanProv-ince，410006，China)Abstract:ObjectiveToevaluatetheeffectofHemerocallisflavone(HCF)onoxidativestressinbrainandlivertissuesofAlzheimer＇sdisease(AD)rats，andtoexplorethepossibilityofusingittoreducethelevelofADoxidativestress．MethodsTwenty-fourSDratswererandomlydividedintothreegroups:blankcontrolgroup，ADmodelcontrolgroup，andHCFgroup．ADmodelwasestablishedbyga-vageofaluminumchlorideandintraperitonealinjectionofDgalactose;Malondialdehyde(MDA)content，superoxidedismutase(SOD)andcatalase(CAT)activityinbrainandliverhomogenatesofratsineachgroupweredetected;Singlefactoranalysisofvariancewasusedfordataanalysis，andLSD-ttestwasusedforintergroupcomparison．ＲesultsComparedwiththeblankcontrolgroup，thecontentofMDAinthebraintissueofADmodelratsincreased，whiletheactivityofSODandCATdecreased;ComparedwiththeADmodelgroup，theHCFgroupshowedadecreaseinMDAc...
