·论著·收稿日期:2022-04-18基金项目:云南省卫生科技计划项目(2018NS0258)。作者简介:孟德欣(1996~)女,在读硕士研究生,研究方向为慢性肾脏病。通信作者:周晓萍,E-mail:1332375914@qq.com。血清胱抑素C评估IgA肾病患者病理损伤及早期肾损害的价值*孟德欣,何荟,周晓萍△(昆明理工大学附属医院/云南省第一人民医院肾内科,云南昆明650032)摘要:目的研究血清CysC评估IgA肾病患者病理损伤与早期肾损害的价值。方法回顾性分析2019年10月-2021年10月于云南省第一人民医院肾内科经肾穿刺活检确诊为IgA肾病的患者200例。根据Lee氏分级标准及eGFR水平进行分组,收集患者相关临床及病理资料。结果在Lee氏分级分组中,随着病理损伤程度的加重,患者血清CysC、SCr、BUN、UA水平逐渐升高,各组中血清CysC的异常检出率均高于SCr、BUN、UA(P<0.001)。在肾功能分组中,随着eG-FR的下降,患者血清CysC、SCr、BUN、UA水平逐渐升高,肾功能正常组及轻度肾损害组患者血清CysC的异常检出率高于SCr、BUN、UA(P<0.001)。Pearson相关性分析显示:血清CysC与Lee氏分级呈正相关(r=0.480,P<0.001),与eGFR呈负相关(r=-0.870,P<0.001)。结论血清CysC是评估IgA肾病患者病理损伤及早期肾损害的灵敏指标。关键词:血清胱抑素C;IgA肾病;病理损伤;早期肾损害中图分类号:R692文献标志码:A文章编号:1006-4141(2023)01-0006-05ThevalueofserumcystatinCintheevaluationofpathologicalinjuryandearlyrenaldamageinpatientswithIgAnephropathyMENGDexin,HEHui,ZHOUXiaoping(DepartmentofNephrology,AffiliatedHospitalofKunmingUniversityofScienceandTechnology/TheFirstpeople'sHospitalofYunnanProvince,KunmingYunnan650032,China)Abstract:ObjectiveTostudythevalueofserumCysCinevaluatingpathologicalinjuryandearlyrenaldamageinpatientswithIgAnephropathy.MethodsAretrospectiveanalysiswasperformedon200patientsdiagnosedwithIgAnephropathythroughrenalbiopsyintheDepartmentofNephrology,TheFirstPeople'sHospitalofYunnanProvincefromOctober2019toOctober2021.ThepatientsweredividedintogroupsaccordingtoLee'sclassificationstandardandeGFRlevel,andtherelevantclinicalandpathologicaldatawerecollected.ResultsInLee'sgradinggroup,thelevelsofCysC,SCr,BUNandUAincreasedgraduallywiththeaggravationofpathologicalinjury,a...