△通信作者血清CEA、CA199表达水平与食管癌TNM分期的相关性分析贺文艳1高月2△(1.榆林市中医医院检验科,陕西榆林719000;2.榆林市中医医院输血科,陕西榆林719000)摘要目的探讨与分析血清癌胚抗原(CEA)、糖类抗原199(CA199)表达水平与食管癌TNM分期的相关性。方法选择在本院诊治的食管癌患者80例作为食管癌组,选择同一时期医院接受检查的80例健康体检者为对照组。检测所有入选者的血清血清CEA、CA199表达水平,调查食管癌的TNM分期并进行相关性分析。结果在食管癌患者中,病理诊断为T1分期34例,T2分期36例,T3分期6例,T4分期4例;N0分期65例,N1分期15例;M0分期67例,M1分期13例。食管癌组的血清CEA、CA199表达水平明显高于对照组(P<0.05)。在食管癌患者中,不同TNM分期患者的血清CEA、CA199表达水平对比有明显差异(P<0.05)。Spearsman分析显示血清CEA、CA199表达水平与T分期、N分期、M分期都存在正相关性(P<0.05)。结论食管癌患者多伴随有血清CEA和CA199高表达,且CEA、CA199表达水平与食管癌TNM分期存在正相关性。关键词癌胚抗原;糖类抗原199;食管癌;T分期;N分期;M分期;相关性CorrelationanalysisofserumCEAandCA199expressionlevelswithTNMstagingofesophagealcancerHeWenyan1,GaoYue2△.1.DepartmentofClinicalLaboratory,YulinHospitalofTraditionalChineseMedicine,Yulin719000,Shanxi,China;2.DepartmentofBloodTransfusion,YulinHospitalofTraditionalChi-neseMedicine,Yulin719000,Shanxi,China.AbstractObjectiveToinvestigateandanalyzethecorrelationbetweentheexpressionlevelsofcarcinoembryonicantigen(CEA)andcarbohydrateantigen199(CA199)inserumandTNMstagingofesophagealcancer.Methods80patientswithesophagealcancerdiagnosedandtreatedinourhospitalwereselectedastheesophagealcancergroup,and80healthypatientswhoreceivedexaminationsinourhospitalduringthesameperiodwereselectedasthecontrolgroup.TheexpressionlevelsofCEAandCA199intheserumofalltheselectedpatientsweredetected.TNMstag-ingofesophagealcancerwasinvestigatedandcorrelationanalysiswasconducted.ResultsAmongthepatientswithe-sophagealcancer,34caseswerediagnosedwithT1stage,36caseswithT2stage,6caseswithT3stageand4caseswithT4stage.65patientshadN0stagingand15patientshadN1staging.Therewere67caseswithM0stagingand13caseswithM1staging.Theseru...
