中国药理学与毒理学杂志2023年9月第37卷增刊1ChinJPharmacolToxicol，Vol37，Suppl1,Sep2023制涉及抑制炎症反应、调节线粒体自噬、逆转HPA轴异常与神经保护等方面，且该方中主要有效成分包括马钱苷、松果菊苷、五味子醇甲等。本文旨在对近年地黄饮子治疗AD和PD的临床疗效、作用机制、有效成分进行梳理，总结并分析地黄饮子在神经退行性疾病中的研究现状，为该复方后续深入的临床及机制研究提供方向和参考。关键词：地黄饮子；阿尔茨海默病；帕金森病；肾精亏虚；药理机制基金项目：国家自然科学基金项目（82004078）；山东省自然科学项目（ZR2021LZY018）；山东省自然科学基金重大基础研究项目（ZR2020ZD17）；泰山学者工程专项（tsqn202211137）；山东中医药大学中医药与脑科学青年科研创新团队（22202101）；山东省医药卫生科技发展计划项目（202201020555）作者简介：任金凤，E-mail：2022111449@sdutcm.edu.cn通讯作者：耿希文，E-mail：xwgeng@sdutcm.edu.cn；魏盛，E-mail：weisheng@sdutcm.edu.cnZ2-1-13Alteredfearengramencodingunderlyingcon⁃ditionedversusunconditionedstimulusiniti⁃atedmemoryupdatingTENGShuaiwen,WANGXinrong,DUBowen,CHENXiaolin,FUGuanzhou,LIUYunfei,XUShuqi,SHUAIJiachen,CHENZheyu(DepartmentofAnatomyandNeurobiology,Shan⁃dongProvincialKeyLaboratoryofMentalDisor⁃ders,SchoolofBasicMedicalSciencesandQiluhospital,CheelooCollegeofMedicine,ShandongUniversity,Jinan250012,China)Abstract:OBJECTIVEIt′sknownthatpost-retrievalextinctionbutnotextinctionalonecoulderasefearmemory.However,whetherthecodingpatternoforiginalfearengramsisremod⁃eledorinhibitedremainslargelyunclear.Herewetrytoinvestigatewhetherthecodingpatternofmemoryengramsisalteredduringpost-retrievalextinctioninducedmemoryupdating.METHODSToanswerthequestion,byusingactivity-depen⁃dentneuronal-taggingtechnology,neuronaltrac⁃ingtechniquecombinedwithoptogeneticmanipu⁃lationandinvivocalciumimaging,weidentifiedthefearandextinctioncellsinPrLandBLAandinvestigatedthedynamicencodingofmemoryengramensemblesinthePrLandBLAduringCSversusUSinitiatedmemoryupdating.RESULTSWefoundincreasedreactivationofengramcellsintheprelimbiccortexandbasolat⁃eralamygdaladuringmemoryupdating.Mor...
