临床用药研究布地奈德福莫特罗治疗咳嗽变异型哮喘疗效分析汪摇勇摇(中南财经政法大学医院,湖北摇武汉摇430070)[摘摇要]摇目的:探讨应用布地奈德福莫特罗治疗咳嗽变异型哮喘(CVA)的效果。方法:应用随机数字表法分组方式,将90例CVA患者分成甲乙丙每组各30例,甲组应用布地奈德治疗,乙组应用福莫特罗治疗,丙组应用布地奈德福莫特罗治疗,比较各组治疗前与治疗8周肺功能[第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰流速(PEF)]、炎性指标[细胞间黏附分子鄄1(ICAM鄄1)与嗜酸细胞活化趋化因子(Eotaxin)]及临床疗效。结果:治疗8w三组FEV1、FVC、PEF明显高于治疗前,而丙组高于甲乙两组,差异有统计学意义(P<0郾05);治疗8w三组ICAM鄄1、Eotaxin明显低于治疗前,而丙组低于甲乙两组,差异有统计学意义(P<0郾05),治疗后甲乙两组肺功能与炎性指标差异无统计学意义(P>0郾05);丙组治疗总有效率90郾00%高于甲组66郾67%与乙组63郾33%,差异有统计学意义(P<0郾05),甲乙两组总有效率差异无统计学意义(P>0郾05)。结论:采取布地奈德福莫特罗治疗CVA的疗效明显高于单纯布地奈德或福莫特罗给药治疗,显著提高患者肺功能,下调血清ICAM鄄1、Eotaxin水平,缓解炎性反应。[关键词]摇布地奈德福莫特罗;咳嗽变异型哮喘;肺功能;细胞间黏附分子鄄1;嗜酸细胞活化趋化因子Analysisoftheefficacyofcoughmutantasthmainthetreatmentofcoughmutations摇摇WANGYong(HospitalofZhongnanUniversityofEconomicsandLaw,Wuhan430070,China)Abstract:ObjectiveToinvestigatetheeffectofapplyingBaconadefforotratotreatcoughvariantasthma(CVA)郾Method90pa鄄tientswithCVAweredividedintoA,BandCgroupsbyrandomnumbertable郾GroupAwastreatedwithBudesonide,groupBwastreatedwithformoterol,andgroupCwastreatedwithbudesonideformoterol,Thepulmonaryfunction[forcedexpiratoryvolumeinthefirstsecond(FEV1),forcedVitalcapacity(FVC),peakexpiratoryflowrate(PEF)],inflammatoryindicators[Intercellularadhe鄄sionmolecule1(ICAM-1)andeosinophilactivatedchemotacticfactor(Eotaxin)]andclinicalefficacywerecomparedbeforeandaf鄄ter8weeksoftreatmentineachgroup郾ResultsAfter8weeksoftreatment,theFEV1,FVC,andPEFlevelsingroup3weresignifi鄄cantlyhigherthanbeforetreatment,whileingroupCtheywerehigherthanthoseingroupAandgroupB,withastatisticallysignificantdifference(P<0郾0...
