收稿日期:２０２３Ｇ０２Ｇ２０基金项目:吴阶平医学基金会临床科研专项资助(３２０．６７５０．２０２１Ｇ１０Ｇ２０)作者简介:邹芳芳(１９８３—),女,硕士,副主任医师,主要从事乳腺肿瘤病理的研究.通信作者:秦春新,副主任医师,EＧmail:qcxwh００１＠１６３．com.SWI/SNF中BAF和PBAF复合物在乳腺癌中的作用邹芳芳１a,张振坤２,秦春新１b(山东大学附属威海市立医院a．病理科;b．乳腺外科,山东威海２６４２００;２．寿光市人民医院肿瘤科,山东寿光２６２７００)摘要:由于人口老龄化、环境恶化和一些不良生活习惯的出现,乳腺癌发病率和致死率位居女性恶性肿瘤的首位.SWI/SNF复合物中BAF和PBAF染色质重塑复合物在转录机制中起至关重要的作用,全基因组测序发现癌症中SWI/SNF复合物发生约２０％的突变.文章综述BAF和PBAF复合物与乳腺癌相关研究进展,并讨论各亚基在乳腺癌形成和发展机制中的重要作用.关键词:乳腺癌;BAF和PBAF复合物;SWI/SNF复合物中图分类号:R７３７．９文献标志码:A文章编号:２０９５Ｇ４７２７(２０２３)０３－００８９－０４DOI:１０．１３７６４/j．cnki．ncdm．２０２３．０３．０１９RoleofBAFandPBAFComplexesinSWI/SNFinBreastCancerZOUFangＧfang１a,ZHANGZhenＧkun２,QINChunＧxin１b(１a．DepartmentofPathology;b．DepartmentofBreastSurgery,WeihaiMunicipalHospitalAffiliatedtoShandongUniversity,Weihai２６４２００,China;２．DepartmentofOncology,ShouguangPeople’sHospital,Shouguang２６２７００,China)ABSTRACT:Duetopopulationaging,environmentaldegradationandunhealthylivinghabits,breastcancerhasthehighestincidenceandmortalityamongfemalemalignanttumors．TheSWI/SNFchromatinremodelingcomplexesBAFandPBAFplayacrucialroleintranscriptionalmechＧanisms．GenomeＧwidesequencingtechnologyidentifiesapproximately２０％ofcancersthathavemutatedSWI/SNFcomplexsubunits．ThisarticlereviewstheresearchprogressincorrelationbeＧtweenBAFandPBAFcomplexesandbreastcancer,anddiscussestheimportantroleofeachsubＧunitintheformationanddevelopmentmechanismsofbreastcancer．KEYWORDS:breastcancer;BAFandPBAFcomplexes;SWI/SNFcomplex根据«２０２０年全球癌症统计数据»,乳腺癌的发病率和病死率仍居女性恶性肿瘤之首,其发病率为２４．５％,病死率为１５．５％[１].虽然对乳腺癌发病机制及治疗的...
