��国际妇产科学杂志2023年6月第50卷第3期JIntObstetGynecol，June2023，Vol.50，No.3DNA甲基化预测宫颈癌及癌前病变的研究进展吴若兰，邱丽华△【摘要】近年来随着早期筛查的普及，我国的宫颈癌发病率及死亡率均有所下降，细胞学检查及高危型人乳头瘤病毒（humanpapillomavirus，HPV）检测是目前常用的宫颈癌筛查手段，但二者均有局限性，细胞学检查可能导致疾病漏诊，而高危型HPV检测常导致过度诊疗，因此，探索一种新的宫颈癌筛查或分流手段十分必要。DNA甲基化是一种常见的表观遗传方式，随着DNA甲基化检测技术的发展，其在肿瘤诊疗领域发挥越来越大的作用。近年来发现许多甲基化基因可作为宫颈癌标志物，在宫颈癌筛查及分流方面具有应用前景，并且具有预测疾病转归、采样方便等优势，有利于宫颈癌的早期诊断及治疗。综述DNA甲基化在宫颈癌及宫颈癌前病变中的相关研究进展。【关键词】DNA甲基化；宫颈肿瘤；癌前状态；癌症早期检测；乳头状瘤病毒科ResearchProgressonDNAMethylationinPredictingCervicalCancerandPrecancerousLesionsWURuo-Lan,QIULi-hua.DepartmentofObstetricsandGynecology,ShanghaiKeyLaboratoryofGynecologicOncology,RenJiHospital,SchoolofMedicine,ShanghaiJiaoTongUniversity,Shanghai200127,ChinaCorrespondingauthor:QIULi-hua,E-mail:lilyqiulh@126.com【Abstract】Inrecentyears,withthepopularizationofearlyscreening,theincidenceandmortalityrateofcervicalcancerinChinahavedecreased.Cytologicalexaminationandhigh-riskhumanpapillomavirus(HPV)testarecommonscreeningmethodsforcervicalcanceratpresent,buttheybothhavetheirlimitations.Cytologicalexaminationmayleadtomisseddiagnosis,whilehigh-riskHPVtestmayleadtoover-diagnosisandover-treatment.Therefore,itisnecessarytoexploreanewscreeningortriagemethodforcervicalcancer.DNAmethylationisacommonepigeneticmodality.WiththedevelopmentofDNAmethylationdetectiontechnology,DNAmethylationhasplayedanincreasinglyimportantroleinthefieldofoncologydiagnosisandtreatment.Inrecentyears,alargeamountofDNAmethylationgeneshasbeenfoundasmarkersofcervicalcancer,whichhaveapromisingapplicationincervicalcancerscreeningandtriage,andhavetheadvantagesofprognosispredictionandconvenientsampling.DNAmethylationisbeneficialforth...
