沈阳医学院学报JournalofShenyangMedicalCollege第25卷第4期2023年7月·综述综述·MiRNA与宫颈癌的相关性及潜在临床意义丁瑶瑶1，楚娟2，陈凡1，朱姣姣1，张倩倩1，秦天生1*，魏林珍1，田青霞3（1.甘肃中医药大学第一临床医学院甘肃省人民医院妇产科，甘肃兰州730000；2.甘肃省陇南市西和县人民医院；3.兰州大学第一医院介入医学科）［摘要］宫颈癌是女性的恶性肿瘤之一，严重威胁女性健康。宫颈癌的早期诊断和有效的治疗可以提高患者的预后。miR‐NAs是一种非编码RNA，与人类的多种肿瘤相关。研究发现，miRNAs对宫颈癌细胞的增殖、分化、凋亡调控有重要影响，与淋巴结转移、宫颈癌进展和不良预后密切相关。已有研究证明，miRNAs是宫颈癌预后、诊断和治疗相关的新生物标志物。本文总结了miRNAs在宫颈癌发病机制中的作用靶点和相关的网络途径，说明了miRNAs与宫颈癌的相关性和潜在临床意义。［关键词］miRNA；宫颈癌；治疗；预后［中图分类号］R737.33［文献标识码］A［文章编号］1008-2344（2023）04-0415-04doi：10.16753/j.cnki.1008-2344.2023.04.019CorrelationbetweenmiRNAandcervicalcanceranditspotentialclinicalsignificanceDINGYaoyao1，CHUJuan2，CHENFan1，ZHUJiaojiao1，ZHANGQianqian1，QINTiansheng1*，WEILinzhen1，TIANQingxia3（1.DepartmentofGynecologyandObstetrics，TheFirstClinicalMedicineCollegeofGansuUniversityofChineseMedicine，GansuProvincialHospital，Lanzhou730000，China；2.XiheCountyHospital；3.TheFirstHospitalofLanzhouUnversity）［Abstract］Cervicalcancerisoneofthemalignanttumorsinwomen，whichseriouslythreatenswomen'shealth.Earlydiagnosisandeffectivetreatmentofcervicalcancercanimprovetheprognosisofpatients.miRNAsareaclassofnon-codingRNAsthatareassociatedwithavarietyoftumors.StudieshavefoundthatmiRNAsplayanimportantroleinregulatingtheproliferation，differentiationandapoptosisofcervicalcancercells，andarecloselyrelatedtolymphnodemetastasis，cervicalcancerprogressionandpoorprognosis.IthasbeenprovedthatmiRNAsarenewbiomarkersrelatedtotheprognosis，diagnosisandtreatmentofcervicalcancer.ThisreviewsummarizesthetargetsandrelatednetworkpathwaysofmiRNAsinthepathogenesisofcervicalcancer，andillustratesthecorrelationandpotentialclinicalsignifica...
