·49JOURNALOFRAREANDUNCOMMONDISEASES,AUG.2023,Vol.30,No.8,TotalNo.169【第一作者】陈薇，女，主要研究方向：乳腺疾病的临床诊治。E-mail：2329350691@qq.com【通讯作者】陈薇·论著·PD-1、PD-L1在三阴性乳腺癌中的表达及临床意义陈薇*李思荣温丽珊五华琴江医院综合外科(广东梅州514400)【摘要】目的探讨PD-1、PD-L1在三阴性乳腺癌中的表达及临床意义。方法随机纳入我院2020年1月至2021年1月78例乳腺癌患者，按照免疫组化结果分为对照组和观察组各39例，对照组为非三阴性乳腺癌，观察组为三阴性乳腺癌，收集患者手术切除的乳腺癌组织，采用免疫组化法检测乳腺癌组织PD-1，PD-L1的表达，并对免疫组化结果和患者的各种临床特征进行对比分析。结果观察组中PD-1、PD-L1的阳性表达率分别为33.33%和52.78%，均明显高于对照组(P<0.05)。PD-1和PD-L1表达与患者年龄、绝经情况和淋巴结转移是否等无相关性(P>0.05)，但在低分化组和TNMⅢ期患者中PD-1，PD-L1表达的表达又明显升高(P<0.05)。结论三阴性乳腺癌中存在明显的PD-1，PD-L1高表达，并与分化程度和临床分期相关，检测PD-1，PD-L1的表达对三阴性乳腺癌的早期诊断有积极意义，可以将PD-L1信号通路作为三阴性乳腺癌治疗的新靶点进行研究。【关键词】三阴性乳腺癌；PD-L1；免疫治疗【中图分类号】R737.9【文献标识码】ADOI:10.3969/j.issn.1009-3257.2023.08.020ExpressionandClinicalSignificanceofPD-1andPD-L1inTriple-NegativeBreastCancerCHENWei*,LISi-rong,WENLi-shan.TraditionalChineseMedicineofMeizhouTianKa-pingHospital,Meizhou514400,GuangdongProvince,ChinaAbstract:ObjectiveToinvestigatetheexpressionandclinicalsignificanceofPD-1andPD-L1intriple-negativebreastcancer.Methods78patientswithbreastcancerinourhospitalfromJanuary2020toJanuary2021wererandomlyincludedanddividedintocontrolgroupandobservationgroupwith39casesineachgroupaccordingtoimmunohistochemicalresults.Thecontrolgroupwasnon-triple-negativebreastcancer,andtheobservationgroupwastriple-negativebreastcancer.ThebreastcancertissuessurgicallyremovedfrompatientswerecollectedandPD-1tissuesweredetectedbyimmunohistochemicalmethod.TheexpressionofPD-L1wasanalyzed,andtheimmunohistochemicalresultsandvariousclinicalcharacteristicsofpatientswerecompared.ResultsThepositiveexpress...
