2023年4月第30卷第4期噻托溴铵干粉胶囊联合布地奈德雾化吸入治疗ACOS的临床效果及对患者肺功能的影响李雅钦1，杨慧2，姜乐2（南阳市中心医院1综合治疗室，2呼吸与危重症医学科，河南南阳473000）【摘要】目的探讨噻托溴铵干粉胶囊联合布地奈德雾化吸入治疗哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）的临床效果及对患者肺功能的影响。方法50例ACOS患者随机分为两组，对照组采用噻托溴铵干粉胶囊治疗，观察组采用噻托溴铵干粉胶囊联合布地奈德雾化吸入治疗，比较两组的临床疗效、肺功能以及不良反应。结果治疗后，观察组的总有效率显著高于对照组，FEV1/FVC、FEV1%pred均显著高于对照组（P<0.05）。两组的不良反应发生率比较，差异无统计学意义（P>0.05）。结论噻托溴铵干粉胶囊联合布地奈德雾化吸入治疗ACOS效果显著，可有效改善患者的肺功能，且安全性较高。【关键词】噻托溴铵；布地奈德；哮喘-慢性阻塞性肺疾病重叠综合征；肺功能中图分类号：R563文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0479ClinicalEffectofTiotropiumBromideDryPowderCapsuleCombinedwithBudesonideAerosolInhalationintheTreatmentofACOSandItsImpactonPulmonaryFunctionofPatients//LIYaqin1,YANGHui2,JIANGLe2(1ComprehensiveTreatmentRoom,2DepartmentofRespiratoryandCriticalCareMedicine,NanyangCentralHospital,Nanyang473000,China)[Abstract]ObjectiveToexploretheclinicaleffectoftiotropiumbromidedrypowdercapsulecombinedwithbudesonideaerosolinhalationinthetreatmentofasthmaCOPDoverlapsyndrome(ACOS)anditsimpactonpulmonaryfunctionofpatients.Methods50patientswithACOSwererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithtiotropiumbromidedrypowdercapsule,andtheobservationgroupwastreatedwithtiotropiumbromidedrypowdercapsulecombinedwithbudesonideaerosolinhalation.Theclinicalefficacy,pulmonaryfunctionandadversereactionswerecomparedbetweenthetwogroups.ResultsAftertreatment,thetotaleffectiverateoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup,andFEV1/FVC,FEV1%predweresignificantlyhigherthanthoseofthecontrolgroup(P<0.05).Nosignificantdifferencewasfoundintheincidenceofadversereactionsbetweenthetwogroups(P>0.05).ConclusionsTiotropiumbromidedrypowdercapsulecombin...
