2023年2月国际神经病学神经外科学杂志Vol.50No.1第50卷第1期JournalofInternationalNeurologyandNeurosurgeryFeb.2023上皮间质转化与胶质瘤侵袭迁移的研究进展苏元萍1,2，王波1,2，姚旋1,2，袁国强21.兰州大学第二医院神经外科，甘肃兰州7300302.兰州大学第二医院神经外科实验室，甘肃兰州730030摘要：胶质瘤是一种恶性程度高、浸润性生长的颅内原发性肿瘤。肿瘤的侵袭和转移是导致患者预后差的主要原因。上皮细胞-间质细胞转换(EMT)是胶质瘤细胞获得高度迁移和侵入表型特征的关键过程。EMT是一个进化上保守的细胞发育程序，和致癌效应密切相关。该文就EMT与胶质瘤侵袭迁移相关作用机制和靶向治疗进行综述，为胶质瘤的诊疗研究提供理论依据。[国际神经病学神经外科学杂志,2023,50(1):75-80]关键词：胶质瘤；上皮间质转化；侵袭迁移；分子机制；靶向治疗中图分类号：R739.41DOI:10.16636/j.cnki.jinn.1673-2642.2023.01.015Researchadvancesinepithelial-mesenchymaltransitionandtheinvasionandmigra⁃tionofgliomaSUYuanping1,2，WANGBo1,2，YAOXuan1,2，YUANGuoqiang21.DepartmentofNeurosurgery，LanzhouUniversitySecondHospital，Lanzhou，Gansu730030，China2.LaboratoryofNeurosurgery，LanzhouUniversitySecondHospital，Lanzhou，Gansu730030，ChinaCorrespondingauthor：YUANGuoqiang，Email：yuangq08@lzu.edu.cnAbstract：Gliomaisahighlymalignantandinvasiveintracranialprimarytumor，andtumorinvasionandmetastasisisthemaincauseofpoorprognosis.Epithelial-mesenchymaltransition（EMT）isthekeyprocessforgliomacellstoobtainthephe-notypiccharacteristicsofstrongmigrationandinvasionabilities.Asanevolutionarilyconservedcellulardevelopmentpro-cess，EMTiscloselyassociatedwithcarcinogeniceffect.ThisarticlereviewsthemechanismofactionofEMTintheinva-sionandmigrationofgliomaandrelatedtargetedtherapy，soastoprovideatheoreticalbasisforthediagnosisandtreatmentofglioma.［JournalofInternationalNeurologyandNeurosurgery,2023,50(1):75-80］Keywords：glioma；epithelial-mesenchymaltransition；invasionandmigration；molecularmechanism；targetedtherapy神经胶质瘤是脑和脊髓最常见的原发性肿瘤［1］，具有高侵袭性、高复发率和高致死率特点［2］。根据世界卫生组织（WorldHealthOrganization，WHO）最...
