第23卷第2期2023年2月过程工程学报TheChineseJournalofProcessEngineeringVol.23No.2Feb.2023CurrentapplicationanddevelopmentofmicroneedleSiboZHAO,YiruBAO,MinXIE*StateChemicalExperimentTeachingDemonstrationCenter,CollegeofChemistryandMolecularScience,WuhanUniversity,Wuhan,Hubei430072,ChinaAbstract:Microneedlesaremicrometersizedsingleneedlesorneedlearraysthatareproducedbymicrofabricatingtechniques.Microneedlescouldpenetratethestratumcorneumlayeroftheskintoreachthedermallayerwhichisfavorableforpercutaneousdrugdelivery.Microneedleshaveanumberofadvantagesindrugdelivery,comparedwithoraladministration,microneedlescircumventthemetaboliceffectsofthedigestivesystemondrugs,comparedwithinjectionneedles,microneedlesareabletoreducepainandimproveadherencecomplianceinpatients.Duetotheirspecialtransdermalpathwayandprecise,convenientapplicationmethods,microneedlehasalsobecomeahotstudiesareainbiomedicineatpresentandtheirapplicationsinvaccination,tissuefluidextractionandbiomarkerdetection,etc.havebeenwellinvestigated.Accordingtoworkingmechanismsforpercutaneousdrugdelivery,microneedlescanbeclassifiedasfivekinds,includingsolid,coated,dissolving,hollow,andhydrogelmicroneedles.Thisreview,combinedwithrelevantarticlesinthefieldofmicroneedletechnologyinrecentyears,providesabriefoverviewofthetypesandfabricatingmaterialsofmicroneedles,mainlyintroducesthecurrentapplicationsofmicroneedlesinthefieldofdrugdelivery(suchasinsulininjectionfordiabetestreatment,localdrugdeliveryforcancertreatment,vaccination,tissuefluidextractionandbiomarkerdetection,etc.)Besides,ifthemicroneedleswouldbewidelyappliedinthemarkerformedicalapplication,somefactorsincludingmechanicstrength,biologicalsafety,sterilizationprocessandbiologicalstabilityofbiomoleculesonthemicrneedlesshouldbewellconsideredwhicharealsodiscussedinthereview.Atlast,outlooksonmicroneedles'futuredevelopmentareprospected,suchasdevelopingmicroneedlesbaseddrugdeliverysystemforheartattacktreatment,improvingbiologicalstabilityofthebiologicalmoleculesonthemicron...
