2023年4月第30卷第4期急性重症脑梗死患者rt-PA静脉溶栓后出血转化发生状况及影响因素王春丽，王呈呈（河南省驻马店市确山县人民医院神经内科，河南驻马店463200）【摘要】目的探讨急性重症脑梗死患者重组人组织纤溶酶原激活剂（rt-PA）静脉溶栓后出血转化的发生状况及影响因素。方法回顾性分析102例急性重症脑梗死患者的临床资料，统计rt-PA静脉溶栓后出血转化发生情况，经单因素和多因素Logistic回归分析探讨rt-PA静脉溶栓后发生出血转化的影响因素。结果102例急性重症脑梗死患者rt-PA静脉溶栓后出血转化发生率为18.63%（19/102）。单因素分析和多因素Logistic回归分析显示，合并高血压、有酗酒史及治疗前NIHSS评分高是急性重症脑梗死患者rt-PA静脉溶栓后发生出血转化的危险因素（P<0.05）。结论合并高血压、有酗酒史以及治疗前NIHSS评分高是急性重症脑梗死患者rt-PA静脉溶栓后发生出血转化的危险因素，临床需采取针对性干预措施，以减少溶栓后出血转化的发生。【关键词】急性重症脑梗死；重组人组织纤溶酶原激活剂；静脉溶栓；出血转化中图分类号：R743.33文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0577OccurrenceStateandInfluencingFactorsofHemorrhagicTransformationAfterrt-PAIntravenousThrombolysisinPatientswithAcuteSevereCerebralInfarction//WANGChunli,WANGChengcheng(DepartmentofNeurology,QueshanCountyPeople'sHospital,Zhumadian463200,China)[Abstract]ObjectiveToexploretheoccurrencestateandinfluencingfactorsofhemorrhagictransformationafterintravenousthrombolysiswithrecombinanthumantissueplasminogenactivator(rt-PA)inpatientswithacuteseverecerebralinfarction.MethodsTheclinicaldataof102patientswithacuteseverecerebralinfarctionwereretrospectivelyanalyzed.Theoccurrenceofhemorrhagictransformationafterrt-PAintravenousthrombolysiswascounted,andunivariateanalysisandmultivariateLogisticregressionanalysiswereusedtoexploretheinfluencingfactorsfortheoccurrenceofhemorrhagictransformationafterrt-PAintravenousthrombolysis.ResultsTheincidenceofhemorrhagictransformationafterrt-PAintravenousthrombolysisin102patientswithacuteseverecerebralinfarctionwas18.63%(19/102).UnivariateanalysisandmultivariateLogisticregressionanalysisshowedthatcomplicationofhypertensi...
