第41卷第3期2023年6月广东医科大学学报JOURNALOFGUANGDONGMEDICALUNIVERSITYVol.41No.3Jun.2023328病原学特征、血清脑钠肽、降钙素原、C反应蛋白及急性生理学评分与重症肺炎患儿病情进展的关系赵腾飞，王莲，彭东正（广州市花都区妇幼保健院儿科，广东广州510800）摘要：目的探讨病原学特征及血清脑钠肽（BNP）、降钙素原（PCT）、C反应蛋白（CRP）及急性生理学评分（APS）评分与重症肺炎患儿病情进展的关系。方法回顾性分析极重症肺炎患儿与重症肺炎患儿的基本资料、病原学特征、血清BNP、PCT、CRP水平、APS评分，采用logistics回归分析病原学特征、血清BNP、PCT、CRP水平、APS评分与病情进展的关系。结果极重症组革兰氏阴性菌感染率、入院时血清BNP、PCT、CRP水平及APS评分均高于重症组（P<0.05或0.01），革兰氏阳性菌感染率低于重症组（P<0.05）。logistics回归分析提示病原学特征、血清BNP、PCT、CRP水平及APS评分均可能与重症肺炎患儿病情相关（P<0.01）。结论重症肺炎患儿以革兰氏阴性菌感染为主，其革兰氏阴性菌感染、血清BNP、PCT、CRP水平及APS评分均与病情进展密切相关。关键词：重症肺炎；儿童；病原学特征中图分类号：R473.71文献标志码：A文章编号：2096-3610（2023）03-0328-03Relationshipofetiologicalcharacteristics,serumBNP,PCT,CRPandAPSscoreswiththediseaseprogressionofchildrenwithseverepneumoniaZHAOTeng-fei,WANGLian,PENGDong-zheng(DepartmentofPediatrics,MaternalandChildHealthHospitalofHuaduDistrict,Guangzhou510810,China)Abstract:ObjectiveToinvestigatetheRelationshipofetiologicalcharacteristics,serumBNP,PCT,CRPandAPSscoreswiththediseaseprogressionofchildrenwithseverepneumonia.MethodsThebasicdata,etiologicalcharacteristics,serumBNP,PCT,CRPlevelandAPSscoreofchildrenwithextremelyseverepneumoniaandseverepneumoniawereanalyzedretrospectively.Logisticsregressionwasusedtoanalyzetherelationshipbetweenetiologicalcharacteristics,serumBNP,PCTandCRPlevelsandAPSscoreanddiseaseprogression.ResultsTheGram-negativebacterialinfectionrate,andtheserumBNP,PCTandCRPlevelsandAPSscoreatadmissionintheExtremelySevereGroupwerehigherthanthoseintheSevereGroup(P<0.05or0.01).TheGram-positivebacterialinfectionrateintheExtremelySevereGroupwaslowerthanthatintheSevereGroup....
