第41卷第3期2023年6月广东医科大学学报JOURNALOFGUANGDONGMEDICALUNIVERSITYVol.41No.3Jun.202330474例孕妇生殖道B群链球菌感染特点及耐药分析王丹纯1，谢舒涵2（1.汕头市中心医院检验科，广东汕头515041；2.嘉应学院医学院，广东梅州514015）摘要：目的分析孕妇生殖道B群链球菌（GBS）感染特点及耐药情况。方法184例孕妇作阴道分泌物GBS培养及药敏试验，比较GBS阳性（观察组，74例）与GBS阴性（对照组，110例）的临床特征、分娩方式及妊娠结局。结果与对照组比较，观察组孕周较短，顺产率较低，产钳助产率、早产率及胎儿窘迫率均较高（P<0.05或0.01）。GBS对青霉素、氨苄西林、万古霉素、奎奴普丁-达幅普汀、利奈唑胺、替加环素的敏感率均为100.0%，呋喃妥因、左氧氟沙星、莫西沙星敏感率分别为87.5%、72.6%、68.2%；克林霉素及四环素耐药率分别为93.0%和81.5%。结论GBS感染对于孕妇及新生儿可产生不良影响，需合理使用抗生素治疗。关键词：孕妇；生殖道；B群链球菌；耐药性中图分类号：R446.5；R978.1文献标志码：A文章编号：2096-3610（2023）03-0304-04GenitalinfectionanddrugresistanceofgroupBstreptococcusin74pregnantwomenWANGDan-chun1，XIEShu-han2(1.DepartmentofLaboratoryMedicine,ShantouCentralHospital,Shantou515041,China;2.MedicalSchoolofJiayingCollege,Meizhou514015,China)Abastract:ObjectiveToinvestigatetheinfectioncharacteristicsanddrugresistanceofgroupBstreptococcus(GBS)inpregnantwomen.MethodsVaginalGBScultureanddrugsusceptibilitywereperformedin184pregnantwomen.Clinicalfeatures,deliverymodeandpregnancyoutcomesofGBSpositive(observationgroup,n=74)andnegative(controlgroup,n=110)groupswerecompared.ResultsComparedwithcontrolgroup,gestationalageandvaginaldeliverywerelower,whileforcepsdelivery,prematurebirthandfetaldistresswerehigher(P<0.01or0.05)inobservationgroup.Thesensitivityrateswere100.0%forpenicillin,ampicillin,vancomycin,quinupristin-dalupristin,linezolidandtigecycline;87.5%fornitrofurantoin,72.6%forlevofloxacin,and68.2%formoxifloxacin.Resistancerateswere93.0%forclindamycinand81.5%fortetracycline.ConclusionGBSinfectioncancauseadverseeffectsonpregnantwomenandnewborns,andrequiretochoosesuitableantibiotics.Keywords:pregnantwomen;genitalt...
