[基金项目]四川省医学会静脉栓塞症防治(恒瑞)专项科研课题(编号:2019HR46);四川省医学青年创新课题计划(编号:Q20077)[通讯作者]郑祥德胶质纤维酸性蛋白、泛素羧基端水解酶L1联合卒中量表评分在急性脑梗死预后评估中的应用研究刘成,郑祥德,田琳,陈俊霖(四川省达州市中心医院,四川达州635000)[摘要]目的探讨胶质纤维酸性蛋白(GFAP)、泛素羧基端水解酶L1(UCH-L1)联合美国国立卫生研究院卒中量表(NIHSS)对急性脑梗死(ACI)预后的预测价值。方法收集我院124例ACI患者资料(ACI组)及66例正常人(健康组)。比较两组GFAP、UCH-L水平变化;分析不同预后ACI患者GFAP、UCH-L水平及与NIHSS评分的关系;探讨上述指标在ACI治疗预后评估中的价值。结果ACI组GFAP、UCH-L水平及NIHSS评分显著高于健康组,预后良好组GFAP、UCH-L水平及NIHSS评分显著低于预后不良组(P<0.05)。GFAP、UCH-L水平与NIHSS评分、mRS评分均呈正相关关系(P<0.05)。ROC结果示,GFAP、UCH-L及NIHSS评分联合检测AUC为0.774,明显高于各项指标单独检测(P<0.05)。结论GFAP、UCH-LI、NIHSS评分可作为评估ACI患者预后的参考指标,且上述指标联合预测价值更高。[关键词]急性脑梗死;美国国立卫生研究院卒中量表;胶质纤维酸性蛋白;泛素羧基端水解酶L1;预后[中图分类号]R743.3[文献标志码]A[文章编号]1672-6170(2023)03-0133-04Applicationofglialfibrillaryacidicproteinandubiquitincarboxy-terminalhydrolaseL1combinedwithNIHstrokescaleintheprognosisevaluationofacutecerebralinfarctionLIUCheng,ZHENGXiang鄄de,TIANLin,CHENJun鄄lin(DazhouCentralHospital,Dazhou635000,China)[Correspondingauthor]ZHENGXiang鄄de[Abstract]ObjectiveToexplorethepredictivevalueofglialfibrillaryacidicprotein(GFAP)andubiquitincarboxy-terminalhydrolaseL1(UCH-L1)combinedwithNationalInstitutesofHealthStrokeScale(NIHSS)ontheprognosisofacutecerebralinfarction(ACI).MethodsDataof124patientswithACI(ACIgroup)and66normalpersonswerecollectedinourhospital.ThechangesinthelevelsofGFAPandUCH-L1werecomparedbetweenthetwogroups.TherelationshipbetweenthelevelsofGFAPandUCH-L1andtheNIHSSscoresintheACIpatientswithdifferentprognosiswasanalyzed.ThevalueoftheaboveindicatorsintheACItreatmentprognosisevaluationwasexplored.ResultsThelevelsofGFAP,UCH-L1andNIHSSscoresintheACIgroupweresignifican...
