en＆tab=TT＆sl=en＆tl=zh-CN＆text=Brief%20Summary%3A%0AThis%20study%20is%20a%20Phase%201b%2F2%20multi-center%20study%20to%20assess%20the%20safety%2C%20tolerability%2C%20pharmacokinetics%20of%20ABL001%20in%20combination%20with%20Irinotecan%20or%20Paclitaxel%20in%20patients%20with%20advanced%20or%20metastatic%20solid%20tumors.＆op=translate.〔28〕LevyMY，MauroMJ，IssaGC，etal.CML-375:AIM4CMLtrialinpro-gress:aphaseⅢbstudyofasciminibmonotherapyinpatientswithchronicmyeloidleukemiainchronicphase(CML-CP)withandwithoutT315Imutations〔J〕.ClinicalLymphomaMyeloma＆Leuke-mia，2021，21:S334-S335.〔29〕NIH.AstudyoforalasciminibversusotherTKIsinadultpatientswithnewlydiagnosedPh+CML-CP〔EB/OL〕.(2022-02-03)〔2022-02-16〕.https://clinicaltrials.gov/ct2/show/study/NCT04971226?cond=asciminib＆draw=2＆rank=8.〔30〕NIH.Asciminibtreatmentoptimizationin≥3rdlineCML-CP〔EB/OL〕.(2022-01-28)〔2022-02-16〕.https://clinicaltrials.gov/ct2/show/NCT04948333?cond=asciminib＆draw=2＆rank=5.〔31〕NIH.Asciminibroll-overstudy〔EB/OL〕.(2022-01-29)〔2022-02-16〕.https://clinicaltrials.gov/ct2/show/NCT04877522?cond=asciminib＆draw=2＆rank=1.〔32〕Garcia-GutiérrezV，LunaA，Alonso-DominguezJM，etal.Safetyandefficacyofasciminibtreatmentinchronicmyeloidleukemiapatientsinreal-lifeclinicalpractice〔J〕.BloodCancerJ，2021，11(2):1-4.〔33〕GleixnerKV，FilikY，BergerD，etal.Asciminibandponatinibexertsynergisticanti-neoplasticeffectsonCMLcellsexpressingBCＲ-ABL1T315I-compoundmutations〔J〕.AmJCancerＲes，2021，11(9):4470-4484.·药剂·高速旋转式压片机各工艺参数对片剂溶出度影响的研究唐顺，徐秀卉，金晓，徐洪辉，宋远征(杭州康恩贝制药有限公司，浙江杭州310052)摘要:目的文章从压片机在使用过程中的主压力、预压力、强制加料转速、压片速度，四个方面探讨研究其对素片体外溶出度的影响。方法通过单因素试验和正交试验确定四个影响因素之间的大小关系。结果压片过程中的主压力、压片速度、强制加料器转速、预压力在一定的参数范围之内均会对片剂的溶出度产生不同程度影响。结论研究发现，以上四个因素对溶出影响的依次顺序是:主压力＞压片速度＞强...
