2022年医学专题—小儿造血和血液特点(英文)(1).pptVIP免费

DevelopmentoftheHematopoieticSystem&BloodCellCountsDr.JieYu,MD.ProfessorThedepartmentofPediatric,Hematology/OncologyHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第一页，共五十三页。DevelopmentofhematopoieticsystemHematopoieticorgansHematopoieticbloodcellsCharacteristicofcellcountsandhemoglobinRBCandHblevelHemoglobinWBC/Platelet/BloodvolumeAnemiaHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第二页，共五十三页。DevelopmentofHematopoieticSystemHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第三页，共五十三页。HEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第四页，共五十三页。Intheembryoandfetus,constantchangescharacterizeallphasesofhematopoiesis.HEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第五页，共五十三页。HematopoieticOrgans•Fetalhematopoiesis•MesoblasticHematopoiesis•HepaticHematopoiesis•MyeloidHematopoiesis•HematopoiesisafterbirthHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第六页，共五十三页。DevelopmentofHematopoieticOrgansFetalHematopoiesisliver第七页，共五十三页。SITESTIMEPRODUCMeasoblastichematopoisisYolkSac10-14thday3-4wk:primitiveblasts10-12wk:ceasedErythroidHepatichematopoiesisLiverSpleen6-8wk:appear12-16wk:active6mo:diminish/stopatbirthErythroidMyeloidhematopoiesisBonemarrow4mo:start6mo:increase/steadyafterbirth:theonlyErythroidNeutrophilsMacrophagesTable1.FetalHematopoiesisHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第八页，共五十三页。HematopoieticOrgans•Fetalhematopoiesis•Hematopoiesisafterbirth•Bonemarrowhematopoiesis•ExtrmedullaryhematopoiesisHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第九页，共五十三页。•Hematopoiesisafterbirth•Bonemarrowhematopoiesis–Allbloodcellsareproducedinthemarrowafter2ndtrimester–Newbornandearlyinfancy:redmarrow–5-7yr:yellowmarrow•ExtramedullaryhematopoiesisHEMATOLOGY/ONCOLOGY,CHILDREN’SHOSPITAL第十页，共五十三页。HematopoieticOrgans•Hematopoiesisafterbirth•Bonemarrowhematopoiesis•Extramedullaryhematopoiesis–Indiseasesstatus:redcellproductionhematopoietictissue.–bloodproductionexpandstoreplacefattymarrow.–bloodcellsproductionexte...