北京中医药2023年2月第42卷第2期BeijingJournalofTraditionalChineseMedicine，February，2023，Vol.42，No.2药对治疗深静脉血栓形成机制研究[J].北京中医药,2021,40(2):189-194.［25］WHITEGE,WESTSL,CATERINIJE,etal.Massagetherapymodulatesinflammatorymediatorsfollowingsprintexerciseinhealthymaleathletes[J].JFunctMorpholKinesiol,2020,5(1):9.Effectandmechanismoflowdoseurokinasecombinedwithfour-stepmassageinthetreatmentofautogenousarteriovenousfistulathrombosisZHANGJing-tao，HUOPeng-fei，ZHANGJing-jing，LINHui-fang，WANGJuan，ZHENGJian-fang，QINZhen-shu（EmergencyDepartmentofXingtaiMunicipalPeople'sHospital，Xingtai054000，China）ABSTRACTObjectiveToobservetheeffectoflowdoseurokinasecombinedwithfour-stepmassageonautogenousarteriovenousfistula（AVF）thrombosisandexploreitsmechanism.MethodsAtotalof86patientswithAVFthrombosisadmittedtoXingtaiPeople'sHospitalfromMarch2020toMay2021wereselectedanddividedintoobservationgroupandcontrolgroupbyrandomnumbertablemethodwith43casesineachgroup.Thecontrolgroupwasgivenroutinethrombolytictherapywithhigh-doseurokinase，whiletheobservationgroupwasgivenlow-doseurokinasecombinedwithfour-stepmassage，andthetreatmentcourseofbothgroupswasnomorethan3days.Thethrombolyticeffectof2groupswasobserved，thelevelsofcoagulationfunctionindexes［activatedpartialprothrombintime（APTT），prothrombintime（PT），plasmafibrinogen（FIB），D-dimer（D-D）］，plasmaC-reactiveprotein（CRP），solubleendothelialcellproteinCreceptor（sEPCR）andhighmobilitygroupproteinB1（HMGB1）werecomparedbetweenthetwogroupsbeforeandaftertreatment.Treatmentrelatedsideeffectswererecordedin2groups.ResultComparedwiththecontrolgroup，theobservationgrouphadhigherinternalfistularecirculationrate，shorterinternalfistulalysistime，largerinternaldiameterattheorificefistula，andhigherinitialdialysisbloodflowafterdissolution，withstatisticalsignificance（P<0.05）.Aftertreatment，APTTandPTin2groupswerelongerthanthatbeforetreatment，andplasmaFIBandD-D，CRP，sEPCRandHMGB1levelswerelowerthanthatbeforetreatmen...
