NJA中华男科学杂志NationalJournalofAndrologyZhonghuaNanKeXueZaZhi2022，28(11):1138－1143http://www．androl．cnMiniＲeview·综述·基于“肾主生殖”理论探讨少弱精子症的生物学基础赵明1，2，晏斌2综述;高庆和2，郭军2审校(1．北京中医药大学研究生院，北京100029;2．中国中医科学院西苑医院，北京100091)【摘要】在“肾主生殖”理论指导下，古今医家辨治男性不育症以补肾为主，在传承的基础上有所创新和发展。笔者对少弱精子症的认识强调以肾为体，精室为用，提出“肾精亏虚-精室失用”为少弱精子症的核心病机。肾精亏虚是导致少弱精子症的根本原因，精室失用是导致少弱精子症发生和进展的主要因素。生殖微环境紊乱是导致少弱精子症的重要原因之一。从肾论治少弱精子症的生物学基础研究表明，补肾法对生殖微环境具有调节作用。从生殖微环境角度入手，系统揭示“肾精亏虚-精室失用”在少弱精子症发生和病机演变过程中的相应内在分子机制变化，可为临床运用“肾主生殖”理论干预少弱精子症的生物学基础研究提供依据。【关键词】肾主生殖;少精子症;弱精子症;少弱精子症;生物学基础;生殖微环境中图分类号:Ｒ223;Ｒ698+．2文献标志码:Adoi:10．13263/j．cnki．nja．2022．11．012①Biologicalbasisofoligoasthenospermiabasedonthetheoryof"kidneygoverningreproduction"ZHAOMing1，2，YANBin2，GAOQing-he2，GUOJun21．GraduateSchool，BeijingUniversityofChineseMedicine，Beijing100029，China;2．XiyuanHospital，ChinaA-cademyofChineseMedicalSciences，Beijing100091，China【Abstract】Guidedbythetheoryof"kidneygoverningreproduction"，ancientandpresent-dayphysicianstreatmaleinfertilitymainlybytonifyingthekidneys，withsomeinnovationanddevelopmentbasedoninheritance．Ｒelatingoligoasthenospermia(OAS)，theauthoremphasizes"thekidneyasthebaseandtheessencechamberforuse"，andproposes"thedeficiencyofkidneyessenceanddisabilityoftheessencechamber"asthecorepathogenesisofthedisease．KidneyessencedeficiencyistheprimarycauseandessencechamberdisabilityisthemainfactorforthedevelopmentandprogressionofOAS．DisordersinthereproductivemicroenvironmentarealsoimportantcausesofOAS．StudiesonthebiologicalbasisofthetreatmentofOASfromthekidneysuggestthatkidneytonificationhasaregulatoryeffectonthere...
