2023年4月第30卷第4期大承气汤对急性胰腺炎患者肠黏膜功能及恢复进程的影响张耿坤，房汉南，陈淑怀（汕头市潮阳区大峰医院消化内科，广东汕头515154）【摘要】目的探讨大承气汤对急性胰腺炎（AP）患者肠黏膜功能及恢复进程的影响。方法86例AP患者随机分为两组，对照组给予常规治疗，观察组在对照组基础上给予大承气汤治疗，比较两组的肠黏膜功能、恢复进程、临床疗效以及不良反应。结果治疗7d后，观察组的二胺氧化酶、D-乳酸、内毒素均低于对照组，腹痛、腹胀缓解时间及肠道功能恢复时间均短于对照组，总有效率高于对照组（P<0.05）。两组的不良反应发生率比较，差异无统计学意义（P>0.05）。结论大承气汤治疗AP患者可获得较好的临床效果，能够加快疾病恢复进程，改善肠黏膜功能，安全性高。【关键词】急性胰腺炎；大承气汤；肠黏膜功能；恢复进程；临床疗效中图分类号：R2-031文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0487ImpactofDachengqiDecoctiononIntestinalMucosalFunctionandRecoveryProcessofPatientswithAcutePancreatitisZHANGGengkun,FANGHannan,CHENShuhuai(DepartmentofGastroenterology,DafengHospitalofChaoyangDistrict,Shantou515154,China)[Abstract]ObjectiveToexploretheimpactofDachengqidecoctiononintestinalmucosalfunctionandrecoveryprocessofpatientswithacutepancreatitis(AP).Methods86casesofAPpatientswererandomlydividedintotwogroups.Thecontrolgroupwasgivenconventionaltreatment,andtheobservationgroupwastreatedwithDachengqidecoctiononthebasisofthecontrolgroup.Theintestinalmucosalfunction,recoveryprocess,clinicalefficacyandadversereactionswerecomparedbetweenthetwogroups.ResultsAfter7daysoftreatment,thediamineoxidase,D-lacticacidandendotoxinintheobservationgroupwerelowerthanthoseinthecontrolgroup,therelieftimeofabdominalpainandabdominaldistension,andtherecoverytimeofintestinalfunctionwereshorterthanthoseinthecontrolgroup,andthetotaleffectiveratewashigherthanthatinthecontrolgroup(P<0.05).Nosignificantdifferencewasfoundintheincidenceofadversereactionsbetweenthetwogroups(P>0.05).ConclusionsDachengqidecoctioninthetreatmentofpatientswithAPcanachievegoodclinicaleffect,acceleratetherecoveryprocessofthedisease,improveintestinalmucosa...
