2023年4月第30卷第4期不同剂量替罗非班联合PCI治疗急性心肌梗死的临床效果分析罗森堡，朱玉强，邓亚平（河南省信阳市息县人民医院心血管内科，河南信阳464300）【摘要】目的探讨不同剂量替罗非班联合经皮冠状动脉介入（PCI）治疗急性心肌梗死（AMI）的临床效果。方法选取2019年9月至2020年12月我院收治的99例AMI患者，依据术后替罗非班使用剂量的不同分为两组。术中两组均静脉滴注10μg/kg替罗非班，A组术后给予小剂量替罗非班（0．075μg／kg）治疗，B组术后给予常规剂量替罗非班（0．15μg／kg）治疗。比较两组的心功能和凝血功能指标。结果治疗后，A组的LVIDd、LVIDs均低于B组，LVEF、CO、LVFS均高于B组（P＜0．05）。治疗后，A组的TT、APTT、PT均长于B组，FIB水平低于B组（P＜0．05）。结论与常规剂量替罗非班相比，小剂量替罗非班联合PCI治疗可更有效地改善AMI患者的心功能和凝血功能。【关键词】急性心肌梗死；剂量；替罗非班；经皮冠状动脉介入；心功能；凝血功能中图分类号：R542.2+2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0495AnalysisontheClinicalEffectofDifferentDosesofTirofibanCombinedwithPCIintheTreatmentofAcuteMyocardialIn-farction//LUOSenbao,ZHUYuqiang,DENGYaping(DepartmentofCardiology,XixianPeople'sHospital,Xinyang464300,China)[Abstract]ObjectiveToexploretheclinicaleffectofdifferentdosesoftirofibancombinedwithpercutaneouscoronaryintervention(PCI)inthetreatmentofacutemyocardialinfarction(AMI).Methods99patientswithAMIadmittedtoourhospitalfromSeptember2019toDecember2020wereselectedanddividedintotwogroupsaccordingtothedifferentdosesoftirofibanaftersurgery.Bothgroupsreceivedintravenousinfusionof10μg/kgtirofibanduringsurgery.GroupAwastreatedwithlowdoseoftirofiban(0.075μg/kg)aftersurgery,andgroupBwastreatedwithconventionaldoseoftirofiban(0.15μg/kg)aftersurgery.Theindicatorsofcardiacfunctionandcoagulationfunctionofthetwogroupswerecompared.ResultsAftertreatment,LVIDdandLVIDsingroupAwerelowerthanthoseingroupB,andLVEF,COandLVFSwerehigherthanthoseingroupB(P<0.05).Aftertreatment,TT,APTTandPTingroupAwerelongerthanthoseingroupB,andFIBlevelwaslowerthanthatingroupB(P<0.05).ConclusionsComparedwithconventional-dosetirofiban,low-...
