CREDITS:(LEFTTORIGHT)UNIVERSALPICTURES/SCREENPROD/PHOTONONSTOP/ALAMYSTOCKPHOTONASA;H.FORD(JHU);AUTZENETAL.12JANUARY2018•VOL359ISSUE637213112JANUARY2018•VOLUME359•ISSUE6372CONTENTS160,228,&237HowachannelsensescalciumONTHECOVERThecoverillustrationreimaginesthemonsterfirstconjuredinMaryShelley’s1818novel.Twocenturieslater,thestoryofhowthefictionalDr.Frankensteinbuiltacreaturefromscavengedbodypartsandunleasheditontheworldhaslostnoneofitspowertounsettle,andFrankensteinhasbecomeabywordforscientificoverreach.Seepages137and146.Illustration:Craig&KarlINTRODUCTION146After200years,FrankensteinisstillessentialreadingforscientistsByK.KupferschmidtFEATURES148HOWAHORRORSTORYHAUNTSSCIENCEThenoveloffersgristforpsychologistsandsciencehistorians,ammunitionfortechnophobes,andeveninspirationforresearchersByJ.Cohen151CREATINGAMODERNMONSTERAtoolboxforFrankensteinsofthe21stcenturyByD.ShultzandA.Arranz152TAMINGTHEMONSTERSOFTOMORROWAsmallgroupofresearchersisstudyinghowsciencecoulddestroytheworld—andhowtostopthatfromhappeningByK.Kupferschmidt154AGLOSSARYOFFRANKENWORDSMaryShelley’sstoryprovidedtheperfectprefixtonicknameanyunusualcreationByJ.Cohen▶EDITORIALP.137;BOOKSETAL.P.168;LETTERSP.170;VIDEOINSIGHTSPERSPECTIVES156DETECTINGTHEBUILDINGBLOCKSOFAROMATICSDetectionofbenzonitrileinaninterstellarcloudhelpstoconstraininterstellarchemistryByC.JoblinandJ.Cernicharo▶REPORTP.202157IMPROBABLEBIGBIRDSDarwin’sfinchesproveamechanismfortherapidformationofnewspeciesByC.E.Wagner▶REPORTP.224159MALARIAPARASITEEVOLUTIONINATESTTUBEExperimentalevolutionstudiesrevealdrugtargetsandresistancemechanismsByJ.M.Carlton▶RESEARCHARTICLEP.191160TRPMCHANNELSCOMEINTOFOCUSThestructuresofTRPMchannelshelptoexplainhowtheycansenseintracellularcalciumByC.Baeetal.▶REPORTSPP.228&237162COHERENTEXCITATIONSREVEALEDANDCALCULATEDNeutronscatteringandtheoreticalstudiesrevealwavelikeelectronstatesinCePd3ByA.Georges▶RESEARCHARTICLEP.186SCIENCEsciencemag.org156NEWSINBRIEF138NewsataglanceINDEPTH141DOEPUSHESFORUSEFULQUANTUMCOMPUT...
