10689SEPTEMBER2016•VOL353ISSUE6304sciencemag.orgSCIENCE9SEPTEMBER2016•VOLUME353•ISSUE6304CONTENTS1095&1161LocationinfluencestumormetabolismPHOTO:FARHADBABAEINEWSINBRIEF1074NewsataglanceINDEPTH1077CAMPAIGNSETSOUTTOFINDAHOTLIMITTOLIFEDeep-seadrillingexpeditionoffJapantoprobemicrobialboundarybeneathseafloorByP.Voosen1078CANNONBALL!CHINA’SMEGASPLASHINOCEANRESEARCHHugenewnationallab’sresearchprioritiesremainsketchyByK.McLaughlin1079THEATMOSPHERE’SPACEMAKERSKIPSABEATHiccupbodeswetwinterweatherforEuropeByB.Mason1080NOPROOFTHATPREDATORCULLSSAVELIVESTOCK,STUDYCLAIMSNewanalysiscallsformorerigorousstudiesByB.Goldfarb1081ACCUSATIONSFLYAFTERBIGGATESGRANTPanelpromisesverdictonolddisputebetweenWHOandtheUniversityofOxfordByK.KupferschmidtINSIGHTSBOOKSETAL.1088AUTUMNBOOKSTOFALLFORPERSPECTIVES1094ZIKAVACCINETRIALSTherearenewandfamiliarchallengesintheracefortimelyandeffectivevaccinesByM.LipsitchandB.J.Cowling▶EDITORIALP.1073;RESEARCHARTICLEP.11291095LOCATION,LOCATION,LOCATIONTissueoforiginisimportantindetermininghowtumorsrewiretheirmetabolismByK.H.VousdenandM.Yang▶REPORTP.11611096VISUALIZINGEVOLUTIONASITHAPPENSAmeter-scalegrowthplateallowstheevolutionofantibioticresistancetobetrackedByL.McNallyandS.P.Brown▶REPORTP.11471098ASYMMETRYINSUPRAMOLECULARASSEMBLYPhotoresponsiveorganicnanowiresconnecttogoldnanomeshandsiliconelectrodesByS.SlimandF.Rosei1099HOWDAMSCANGOWITHTHEFLOWSmallchangestowaterflowregimesfromdamscanhelptorestoreriverecosystemsByN.L.PoffandJ.C.Schmidt1101LENTIVIRALVECTORS,TWODECADESLATERAdeadlyvirusbecameaneffectivegenedeliverytoolByL.Naldinietal.1103AHMEDH.ZEWAIL(1946–2016)ANobellaureate,whopioneeredfemtochemistry,promotedascientificrenaissanceintheMiddleEastByP.B.Dervan1104DONALDA.HENDERSON(1928—2016)ApragmaticandtirelessepidemiologistledtheinternationaleradicationofsmallpoxByD.L.HeymannPOLICYFORUM1105AU.S.“CANCERMOONSHOT”TOACCELERATECANCERRESEARCHPatientengagementanddatasharingmustimproveByD.S.Singeretal.LETTERS1107NUCLEARENERGY:IMPROVECOLLABORATIONByH.Yan...