■■■■■■■■■■■■■■■■■■■■■■研究论文One-potSynthesisof(E)-Diethyl2-styrylquinoline-3,4-dicarboxylateDerivativesZhaoDi1,LiuYanying2,WangYang3,LiYang1∗(1CollegeofChemistryandMaterialsEngineering,BohaiUniversity,Jinzhou,121000;2ResearchInstituteofJinzhouPetrochemicalCompany,Jinzhou,121000;3CenterofExperimentandEquipmentManagement,BohaiUniversity,Jinzhou,121000)AbstractInthepresentwork,asimpleandflexiblesynthesisofaseriesofnovel(E)-diethyl2-styrylquinoline-3,4-dicarboxylates3a~3iwithgoodyieldshasbeenachieved,involvingone-potsequentialArbuzov/Horner-Wadsworth-Emmons(HWE)reactionsequenceusingdiethyl2-(bromomethyl)quinoline-3,4-dicarboxylateassubstrate.Themolecularstructuresofthesenewlysynthesizedproductswereconfirmedbyspectraldataandelementalanalyses.KeywordsBromomethyl,Styrylquinoline,One-pot,Arbuzovreaction,HWEreaction“一锅法”合成(E)-2-苯乙烯基喹啉-3,4-二酸二乙酯类衍生物赵頔1刘延鹰2王洋3李阳1∗(1渤海大学化学与材料工程学院锦州121000;2锦州石化分公司研究院锦州121000;3渤海大学实验与设备管理中心锦州121000)∗联系人,李阳男,43岁,博士,教授,主要从事有机合成研究。E-mail:bhuzh@163.com国家自然科学基金项目(21878023,U1608222)、辽宁省特聘教授项目、辽宁省教育厅“青年育苗”项目(LQ2019006)和辽宁省科技厅博士启动项目(2019-BS-004)资助2022-07-12收稿,2022-10-09接受摘要本文设计以2-溴甲基喹啉-3,4-二甲酸二乙酯为起始化合物,经一锅连续的Arbuzov反应/Horner-Wadsworth-Emmons(HWE)反应过程,简便而有效地合成了一系列结构新颖的(E)-2-苯乙烯基喹啉-3,4-二羧酸二乙酯类衍生物(3a~3i),其结构均已通过波谱数据和元素分析得以证实。关键词溴甲基苯乙烯基喹啉一锅法Arbuzov反应HWE反应Amongagreatvarietyofquinolinederivatives,2-styrylquinolines(SQLs)formanimportanttypeofstructuralmotifsinmedicinalchemistryandrepresentasignificantcomponentofpharmacolo-gicallyactivemolecules.Membersofthisfamilyhavebeenclaimedtoexhibitawiderangeofbiolo-gicalproperties,suchasanticancer[1],antitumor[2],antimalarial[3],antifungal,antibacterial[4],antimi-crobial[5],andanti-HIVactivities[6].Forexample,styrylquinolineFZ-41(I,Scheme1...
