7OCTOBER2016•VOL354ISSUE63087SCIENCEsciencemag.org7OCTOBER2016•VOLUME354•ISSUE6308CONTENTSNEWSINBRIEF16NewsataglanceINDEPTH18BATTLEOVERRAREDISEASEDRUGENSNARESNIHFirmsandparentsofkidswithfatalconditionclashoverdrugdeliveryandroleofagencyByM.Wadman20NOBELHONORSDISCOVERIESINHOWCELLSEATTHEMSELVESCellularsanitationhelpskeepdiseasesatbayByM.EnserinkandE.Pennisi21TRIOWINSNOBELFOREFFECTSOFTOPOLOGYONEXOTICMATTERWorkpresagedresearchrevolutionintopologicalinsulatorsByA.Cho22EUROPEANXFELTOSHINEASBRIGHTEST,FASTESTX-RAYSOURCEFreeelectronlaser’srapid-firepulseswillprobefree-floatingmoleculesintheirnaturalhabitatByE.Cartlidge23U.S.CHARGESJOURNALPUBLISHERWITHMISLEADINGAUTHORSOMICSGroupInc.hasdrawnnumerouscomplaintsaboutallegedlyshadyeditorialpracticesandmeetingsByJ.Bohannon24FIRSTPOLYNESIANSLAUNCHEDFROMEASTASIATOSETTLEPACIFIC“Game-changing”studyofancientgenomestracesPolynesianrootssolelytoEastAsianfarmersByA.GibbonsONTHECOVERASherpaporteratthebaseoftheKhumbuIceFall,MountEverest.Somehumanpopulationsexhibitgreatertoleranceforhighelevation,duetogeneticvariantsthatlikelymitigatethedeleteriouseffectsoflowoxygenconcentrationsataltitude.Geneticandepigeneticchangesshapeourresponsetotheenvironmentandmayplayaroleindisease.Formoreontheinteractionsbetweengenesandtheenvironment,seepage52.Photo:MaxLowe/NationalGeographicCreativeSPECIALSECTIONGENES&ENVIRONMENTINTRODUCTION52GenesunderpressureREVIEWS54Goingglobalbyadaptinglocal:AreviewofrecenthumanadaptationS.Fanetal.59Transgenerationalinher-itance:Modelsandmechanismsofnon–DNAsequence–basedinheritanceE.A.MiskaandA.C.Ferguson-Smith64Writlarge:GenomicdissectionoftheeffectofcellularenvironmentonimmuneresponseN.YosefandA.Regev69Exposingtheexposuresresponsiblefortype2diabetesandobesityP.W.FranksandM.I.McCarthy▶EDITORIALP.1538&81INSIGHTSPERSPECTIVES32GROWINGASYNTHETICMOLLUSKSHELLThree-dimensionalorganictemplatescontrolcalciumcarbonateprecipitationByF.Barthelat▶REPORTP.10734APRAGMATICWAYFORWARD?Trainingofinformalprovidersmayimprovethequalityof...
