·综述·食管癌综合治疗新进展*杨雄涛①综述王鑫②审校摘要食管癌是中国发病率和死亡率均较高的恶性肿瘤，虽然治疗模式多样但总体5年生存率较低。基于手术、放疗、化疗、免疫治疗和靶向治疗的综合治疗方案是目前食管癌的治疗标准。随着食管癌手术术式的革新、放疗靶区及技术的进步、化疗药物和方案的优化以及靶向、免疫治疗的加入，使食管癌患者在不降低生存质量的前提下，获得了更长的生存时间。本文查阅了近期发表的食管癌治疗相关文献，重点回顾了食管癌放疗、免疫治疗等综合治疗相关研究成果并进行汇总，对食管癌围手术治疗、根治性同步放化疗、老年食管癌患者治疗和晚期食管癌免疫治疗的研究进展进行综述。关键词食管癌新辅助放化疗根治性同步放化疗免疫治疗老年患者doi:10.12354/j.issn.1000-8179.2023.20221079RecentprogressinthecomprehensivetreatmentofesophagealcancerXiongtaoYang1,XinWang2Correspondenceto:XinWang;E-mail:beryl_wx2000@163.com1DepartmentofOncology,BeijingChangpingHospital,Beijing102202,China;2DepartmentofRadiationOncology,NationalCancerCenter/NationalClinicalResearchCenterforCancer/CancerHospital,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100021,ChinaThisworkwassupportedbyCAMSInnovationFundforMedicalSciences(No.2021-I2M-C&T-B-072)andChineseSocietyofClinicalOncology-BeijingXisikeClinicalOncologyResearchFoundation(No.Y-SY201901-0004)AbstractEsophagealcancer(EC)isamalignanttumorwithhighmorbidityandmortalityratesinChina.Despitetheavailabilityofvarioustreatmentmodalities,theoverall5-yearsurvivalrateremainslow.Comprehensivetreatment,includingsurgery,radiotherapy,chemother-apy,immunotherapy,andtargetedtherapy,isthecurrentstandardfortreatingpatientswithEC.Nowadays,patientswithECareabletoachievealongersurvivalratewithoutreducingtheirqualityoflifeowingtotheinnovationofsurgicalprocedures,progressofradiotherapytargetsandtechniques,optimizationofchemotherapeuticdrugsandregimens,andadditionoftargettherapyandimmunotherapyforEC.ThispaperreviewedtherecentlypublishedliteratureonthetreatmentofECandsummarizedstudiesontheuseofcomprehensivetreat-ment,includingradiotherapyandimmunotherapy,forEC.Furt...
