2023年2月第30卷第2期尿激酶联合肝素封管预防血透患者长期留置导管功能不良的效果分析罗国平，刘慧琴，苏卫东（清远市清城区人民医院血透室，广东清远511500）【摘要】目的分析尿激酶联合肝素封管预防血液透析患者长期留置导管功能不良的临床效果。方法选取2020年6月至2021年7月在我院使用留置导管行血液透析的60例患者，随机分成两组各30例。对照组采用肝素封管，观察组采用尿激酶联合肝素封管。比较两组的导管堵塞率、溶栓再通率以及透析时的血流量、静脉压和尿素清除指数（Kt/V）。结果观察组的导管堵塞率显著低于对照组，溶栓再通率显著高于对照组（P<0.05）。末次透析时，两组的血流量、Kt/V均显著低于首次透析时，静脉压均显著高于首次透析时（P<0.05）；与对照组相比，观察组末次透析时的血流量、Kt/V均显著更高，静脉压显著更低（P<0.05）。结论尿激酶联合肝素封管可有效预防血液透析患者长期留置导管功能不良，提高透析效果。【关键词】尿激酶；肝素；血液透析；长期留置导管功能不良中图分类号：R459.5文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0207AnalysisontheEffectofUrokinaseCombinedwithHeparinforTubeSealinginPreventionofLong-TermIndwellingCatheterDysfunctioninHemodialysisPatients//LUOGuoping,LIUHuiqin,SUWeidong(HemodialysisRoom,QingyuanPeople'sHospital,Qingyuan511500,China)[Abstract]ObjectiveToanalyzetheclinicaleffectofurokinasecombinedwithheparinfortubesealinginpreventionoflong-termindwellingcatheterdysfunctioninhemodialysispatients.Methods60patientswhounderwenthemodialysiswithindwellingcatheterinourhospitalfromJune2020toJuly2021wereselectedandrandomlydividedintotwogroups,with30casesineachgroup.Thecontrolgroupwassealedwithheparin,andtheobservationgroupwassealedwithurokinasecombinedwithheparin.Thecatheterobstructionrate,thrombolyticrecanalizationrate,andbloodflow,venouspressureandureaclearanceindex(Kt/V)duringdialysiswerecomparedbetweenthetwogroups.ResultsThecatheterobstructionrateoftheobservationgroupwassignificantlylowerthanthatofthecontrolgroup,andthethrombolyticrecanalizationratewassignificantlyhigherthanthatofthecontrolgroup(P<0.05).Atthelastdialysis,thebloodflowandKt/Vofthetwogroupsweresignificantlylowerthanthose...
