CHINAMEDICINEANDPHARMACYVol.13No.2January20231442023年1月第13卷第2期·临床医学·肿瘤雷替曲塞同步放疗治疗晚期食管癌的效果观察徐保辰山东省新泰市人民医院肿瘤三科,山东新泰271200[摘要]目的探讨晚期食管癌患者给予雷替曲塞同步放疗治疗的效果。方法选取2020年8月至2021年9月新泰市人民医院收治的74例晚期食管癌患者作为研究对象,采用随机数表法将其分为观察组(n=37)与对照组(n=37)。对照组采用放疗治疗,观察组在对照组基础上加用雷替曲塞治疗。比较两组患者的近期疗效、肿瘤标志物及不良反应。结果观察组患者客观缓解率(ORR)、疾病控制率(DCR)均高于对照组,差异有统计学意义(P<0.05);两组患者治疗后癌胚抗原(CEA)、鳞状上皮细胞癌相关抗原(SCC)水平低于本组治疗前,观察组患者治疗后CEA、SCC水平低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论晚期食管癌患者给予雷替曲塞同步放疗治疗,能够提高近期疗效,改善患者肿瘤标志物水平,且未增加不良反应。[关键词]晚期食管癌;雷替曲塞;放疗;近期疗效;肿瘤标志物;不良反应[中图分类号]R735.1[文献标识码]A[文章编号]2095-0616(2023)02-0144-04ObservationonthetherapeuticefficacyofconcurrentradiotherapywithraltitrexedinthetreatmentofadvancedesophagealcancerXUBaochenDepartmentⅢofOncology,thePeople’sHospitalofXinTaiCity,Shandong,Xintai271200,China[Abstract]ObjectiveToexploretheefficacyofconcurrentradiotherapywithraltitrexedinpatientswithadvancedesophagealcancer.MethodsAtotalof74advancedesophagealcancerpatientswhowereadmittedinthePeople’sHospitalofXinTaiCityfromAugust2020toSeptember2021wereselectedastheresearchobjects,andbytherandomnumbertablemethod,theyweredividedintotheobservationgroup(n=37)andthecontrolgroup(n=37).Radiotherapywastreatedinthecontrolgroup,raltitrexedonthebasisofthecontrolgroupwastreatedintheobservationgroup.Theshort-termtherapeuticefficacy,tumormarkersandadversereactions(ARs)inbothgroupswerecompared.ResultsComparedwiththecontrolgroup,theobjectiveremissionrate(ORR)anddiseasecontrolrate(DCR)ofpatientsintheobservationgroupwereallhigher(P<0.05).Thelevelsofcarcinoembryonicantigen(CEA)andsquamouscellcarci...