《转化医学杂志》2022年12月第11卷第6期TranslationalMedicineJournal,Vo1.11NO.6,Dec2022氨甲环酸在手术患者中的应用进展刘迎壮,李纳,杨庆彬,周琦,焦勇强,赵素斌[摘要]手术过程中出血是较为常见的一种情况,术中出血会造成严重的低血压,心肺肾损伤等严重的并发症,增加手术的难度,使患者预后不佳。纤维蛋白溶解亢进导致的术中出血是主要原因之一。目前氨甲环酸(Tranexamicacid,TXA)是抗纤维蛋白溶解剂中应用最广泛的一类药物。TXA的使用可以有效减少手术过程中的出血,但其在手术中的应用途径、剂量等有所争议。本文搜集文献,总结了TXA在几种手术过程中的最新应用数据。探讨TXA的临床使用,了解TXA在临床手术中使用情况,最大程度减少出血的发生。[关键词]氨甲环酸;手术;纤溶酶[中图分类号]R65[文献标志码]A[文章编号]2095-3097(2022)06-0402-04doi:10.3969/j.issn.2095-3097.2022.06.017ApplicationprogressoftranexamicacidinsurgicalpatientsLIUYingzhuang1,LINa2,YANGQingbin1,ZHOUQi1,JIAOYongqiang3,ZHAOSubin4(1.CollegeofClinicalMedicine,HebeiUniversityofEngineering,HandanHebei056004,China;2.DepartmentofCar‐diology,XingtaiPeople'sHospital,XingtaiHebei054000,China;3.DepartmentofOrthopaedics,AffiliatedHospitalofHebeiUniversityofEngineering,HandanHebei056004,China;4.DepartmentofGeneralSurgery,AffiliatedHospitalofHebeiUniversityofEngineering,HandanHebei056004,China)[Abstract]Hemorrhageduringoperationisarelativelycommoncondition,whichwillcauseseverehypotension,cardiopulmonaryrenalinjuryandotherseriouscomplications,increasethedifficultyofoperation,andmaketheprogno‐sisofpatientspoor.Intraoperativehemorrhagecausedbyhyperfibrinolysisisoneofthemaincauses.Atpresent,tranexamicacid(TXA)isthemostwidelyusedclassofantifibrinolyticagents.TheuseofTXAcaneffectivelyreducethebleedingduringsurgery,butthewayanddosageofitsapplicationinsurgeryarecontroversial.ThisarticlecollectedtheliteratureandsummarizedthelatestapplicationdataofTXAinseveralsurgicalprocedures.ToexploretheclinicaluseofTXA,understandtheuseofTXAinclinicalsurgery,andminimizetheoccurrenceofbleeding.[Keywords]Tranexamicacid;Surgery;Fibrinolyticenzyme目前,在手术过程中出...