MUC5AC在胃型宫颈腺癌组织中的表达及其临床病理特征褚小莹1,2，周永泽1,2*（1武汉大学中南医院病理科，武汉430071；2武汉大学病理中心，武汉430071）〔摘要〕目的分析胃型宫颈腺癌(gastric-typeendocervicaladenocarcinoma,GAS)组织病理形态学特点，检测MUC5AC在该癌组织中的表达，研究GAS免疫组织化学表型特点及相关特征，并结合AB-PAS特殊染色结果探究GAS潜在诊断方法。方法回顾性分析2019年7月1日至2020年12月31日于武汉大学中南医院就诊的5例GAS患者的临床资料，总结其临床表现、病理特征、免疫表型及AB-PAS特殊染色特点。结果免疫组织化学检测显示，5例GAS患者癌组织CK7、MUC6、CEA及MUC5AC阳性，p16、MUC2、CDX2、ER及PR阴性，Pax8表达不稳定，p53均为野生型表达，Ki-67多为阳性高表达。AB-PAS染色显示胞质均呈现红色。结论与普通型宫颈腺癌相比，GAS具有易被误诊的良性组织形态。本研究发现免疫组织化学标志物MUC5AC的稳定阳性表达及AB-PAS染色后胞质呈红色可能是诊断该病的关键性特征。〔关键词〕胃型宫颈腺癌；免疫组织化学染色；MUC5AC；AB-PAS染色〔中图分类号〕R365〔文献标识码〕ADOI：10.16705/j.cnki.1004-1850.2022.06.008ExpressionofMUC5ACingastric-typeendocervicaladenocarcinomaanditsclinicopathologicalfeaturesChuXiaoying1,2,ZhouYongze1,2*(1DepartmentofPathology,ZhongnanHospitalofWuhanUniversity,Wuhan430071,China;2PathologyCenterofWuhanUniversity,Wuhan430071,China)〔Abstract〕ObjectiveTostudythehistopathologicalcharacteristicsofgastric-typeendocervicaladenocarcinoma(GAS);tode-tecttheexpressionofMUC5ACinGAS;toanalyzethephenotypicandrelatedcharacteristicsofGASimmunohistochemicalindexes,andtoexplorethepotentialdiagnosticmethodsofGAScombinedwiththeresultsofAB-PASstaining.MethodsTheretrospectiveanalysiswasperformedinfivepatientswithGASwhoconsultedinZhongnanHospitalofWuhanUniversityfromJuly1,2019toDecember31,2020,andtheirclinicalmanifestations,pathologicalfeatures,immunophenotypesandspecialstainingcharacteristicsofAB-PASweresummarized.ResultsImmunohistochemicalstainingshowedthat5casesofGASpositivelyexpressedwithCK7,MUC6,CEAandMUC5AC,whiletheexpressionofp16,MUC2,CDX2,ERandPRwerenegative.TheexpressionofPax8wasun-stable.p53andKi67werewild-ty...
