第53卷第2期2023年2月Vol.53No.2Feb.2023·121·日用化学工业（中英文）ChinaSurfactantDetergent&CosmeticsReceived:March10,2022;Revised:January28,2023.*Correspondingauthor.E-mail:shangyazhuo@ecust.edu.cn.国家自然科学基金：表面活性剂的界面传递行为研究（No.21476072）DOI：10.3969/j.issn.1001-1803.2023.02.001PreparationofP/O/LC/WmultipleemulsionYawenLv,JingwenWang,ZhichengYe,YazhuoShang*,HonglaiLiu（LaboratoryofCosmetics,SchoolofChemistry&MolecularEngineering,EastChinaUniversityofScienceandTechnology,Shanghai200237,China）Abstract:Atypeofpolyol-in-oil-in-liquidcrystal-in-water（P/O/LC/W）multipleemulsionwaspreparedbytwo-stepmethodwithliquidcrystalemulsifierandtraditionalemulsifier.Thesampleswerecharacterizedbymicroscopy.Theeffectsofdifferentliquidcrystalemulsifiers,emulsificationtemperatureandhomogenizationrateonthemicrostructureofP/O/LC/Wmultipleemulsionwerestudied.Thestepsofpreparationprocesswereasfollows:Theemulsificationtemperaturewas60-75℃;thehomogenizationrateofpolyolinoilwas7000-8400r/minandhomogenizationtimewas~6min;thehomogenizationrateofpolyolinoilinliquidcrystalinwaterwas4400-6000r/minandhomogenizationtimewas~7min.Theemulsionwasputatroomtemperaturefor28days,andmultiplestructuresandliquidcrystalstructurescouldstillbeobserved,andtheliquidcrystalbecamebrighter.Thecomponentsoftheformulawereglycerol（polyolphase）,squalane（oilphase）,P135（hydrophobicemulsifier）,andIST-LC001（liquidcrystalemulsifier）.Theidealemulsionstructurecouldthusbeobtained.Theformulawasusedtoencapsulateactivesubstances.Resveratrolwasusedasthetargetmoleculeforsustained-releaseexperiment.TheresultsofdialysisexperimentsinvitroshowedthattheP/O/LC/Wmultipleemulsionhadaremarkableslow-releaseperformance.Thereleaseratiooftargetmoleculewasupto83%after10h.Whenshikoninwasusedasthetargetmolecule,itwasprovedthattheP/O/LC/Wmultipleemulsioncouldmaskthecolorofthetargetmolecule.Comparedwithtraditionalemulsion,thecolorofP/O/LC/Wmultipleemulsionwaslighter.Rheologicalmeasurementshowedthattheviscosityoftheemuls...
