Designation:E2045−99(Reapproved2014)StandardPracticeforDetailedClinicalObservationsofTestAnimals1ThisstandardisissuedunderthefixeddesignationE2045;thenumberimmediatelyfollowingthedesignationindicatestheyearoforiginaladoptionor,inthecaseofrevision,theyearoflastrevision.Anumberinparenthesesindicatestheyearoflastreapproval.Asuperscriptepsilon(´)indicatesaneditorialchangesincethelastrevisionorreapproval.1.Scope1.1Thispracticedescribesthetermsusedinobservingandrecordingcutaneous,gastrointestinal,respiratory,reproductive,neuromuscular,ocular,andgeneralclinicalsignsofanimalsundergoingtoxicologicaltesting.Thispracticealsoassistsinproperlyobservingandassessinglaboratoryanimalsforsignsofdiseaseoradverseeffectsofcompoundadministration.1.2Thispracticeincludescodesanddescriptionsforawidevarietyofclinicalsigns,anatomicallocations,andotherdescriptivequalifiers,andatechniqueforscoringtheextentorseverityofclinicalsigns.1.3Thispracticeassumesthatthereaderisknowledgeableinanimaltoxicologyandrelatedpertinentareasandistrainedinmakingclinicalobservations.1.4Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappro-priatesafetyandhealthpracticesanddeterminetheapplica-bilityofregulatorylimitationspriortouse.2.ReferencedDocuments2.1FederalStandards:Title40,CodeofFederalRegulations(CFR),EnvironmentalProtectionAgency,SubchapterE,PesticidePrograms,Part160,GoodLaboratoryPracticeStandards2Title40,CodeofFederalRegulations(CFR),ToxicSub-stancesControlAct,Part792,GoodLaboratoryPracticeStandards2Title40,CodeofFederalRegulations(CFR),EnvironmentalProtectionAgency,Part798,HealthEffectsTestingGuidelines23.SignificanceandUse3.1Thispracticepertainstoallformsoftoxicologicaltesting(acute,subchronic,orchronic)performedbyanyrouteofadministration(inhalation,oral,dermal,ocular,orother).3.2TheU.S.EnvironmentalProtectionAgency,GoodLaboratoryPracticesforNonclinicalLaboratoryStudies,aslistedin40CFR,requiresthatatestingfaci...
