系统性红斑狼疮的骨质疏松与皮质激素的相关性.pptVIP免费

GCinducedosteoporosis北京协和医院风湿免疫科张烜IntroductionGCsareeffectiveinmanyrheumaticdiseasesButGCinducedOPisacommonsideeffectTrabecularrichsitesegspine&ribsareespeciallyatriskEffectiveRxcanpreventorreverseGCbonelossOPinRAonGCRx多因素–RA•Osteoclast活化(TNFa，RANK)–Physicalinactivity–GCRx–Menopause不同部位骨丢失不同–Hand>Femur>Spine–腰椎骨丢失与GC强相关PathophysiologyMostofthebiologicalactivitiesmediatedvia–Passageacrosscellmembrane–attachmenttocytosolicGCreceptor–bindingtoGCresponseelement–®ulatinggenetranscriptionMayactviaothertranscriptionfactors:–activatedprotein(AP)-1–NFBGCreceptor&bindingEffectsofGConbonemetaboli...