双膦酸盐和下颌骨坏死李彦博1，刘霏霏2BisphosphonatesandjawosteonecrosisLIYanbo1，LIUFeifei21MedicalDepartment，AffiliatedHospitalofAcademyofMilitaryMedicalSciences，Beijing100071，China;2PharmaceuticalDepartment，AffiliatedHospitalofAcademyofMilitaryMedicalSciences，Beijing100071，China．【Abstract】Objective:Understandingthephysicalandchemicalpropertiesofbisphosphonatesandtheirpharmacolog-icalfeaturesandthesituationofbisphosphonate－relatedosteonecrosisofthejaws(BRONJ)．Methods:Topresentaliteraturereviewonbisphosphonates，focusingontheirpharmacologicalfeaturesandtheirreportedassociationwithjawosteonecrosis．Results:Bisphosphonateshavebeenwidelyprescribedfortreatmentofdiseasescharacterizedbyintenseboneresorption．Thesedrugshavealsobeenassociatedwithaserioussideeffect，avascularosteonecrosisofthejaws．Themorbidityandlackoftreatmentresponseofthisconditionareseriousfactstobeconsideredwhenpre-scribingbisphosphonatetherapy．Therisk－benefitrelationshipneedstobeseriouslyanalyzed，andthetreatmentprosandconsshouldbeexplainedtothepatient．Ifthetherapywithbisphosphonateisindicated，rigorousoralhealthade-quacymustbeperformedandperiodicevaluationoforalconditionsismandatory．Conlousion:Consideringtheseri-ousnessofthepotentialoccurrenceofbisphosphonate－relatedosteonecrosisofthejaws，cautioninprescribingthesedrugsandcarefulobservationofpatientsbeingtreatedwiththemseemstobeindicated．Lesionpreventioninpatientsundergoingbisphosphonatetherapyisessentialtopreventandcontrolmorbidityassociatedwithadvanceddestructivelesions．【Keywords】bisphosphonates;jaw;osteonecrosisModernOncology2012，20(05)1065－1068【摘要】目的:了解双膦酸盐的理化性质和药理学特性以及与其相关的下颌骨坏死的有关情况。方法:综述双膦酸盐和与其相关的下颌骨坏死的文献。结果:双膦酸盐已经被广泛用于治疗以骨吸收为特点的疾病。这些药物也越来越与下颌骨缺血性坏死这种严重的副作用联系在一起。考虑到下颌骨坏死的发生和对其缺乏有效治疗措施的事实，计划使用双膦酸盐治疗时，应认真分析风险－效益的关系，并向病人说明治疗的利弊。如果要使用双膦...
